tumor biology and pathology 1688PD THE COMBINED EXPRESSION OF CXCR7 AND ITS LIGAND CXCL12 IS A MARKER FOR UNFAVORABLE PROGNOSIS IN GASTRIC CANCER
نویسندگان
چکیده
Background: Chemokines and their receptors have been shown to play a critical role in cancer growth and metastasis. In particular, recent data have suggested that the chemokine CXCL12 and its receptor CXCR7 (also known as RDC1), which has been recently identified as a chemokine receptor, have key functions in promoting tumor development and progression. However, there is little information regarding their expression and clinical relevance in gastric cancer. Here we investigated for the first time the effects of combined CXCR7 and CXCL12 expression on the prognosis of patients with gastric cancer.
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